The TV star, 53, insisted today his lack of lines was "genetic" as he revealed "people think I've had plastic surgery I look so good".
On his second day back on Good Morning Britain after several weeks off, he responded to comments about his youthful skin.
He joked to his colleagues: "It's clean living. It's just doing things the right way. No it's just basically a load of cheese and red wine."
Charlotte Hawkins interjected: "Good skin inherited from your mother?"
Piers replied: "You see it's all genetic. I don't smoke, which I think is crucial. But if your mum, your grandma have a lack of lines. You're in business."
Teasing Charlotte, as well as Susanna Reid and weather girl Laura Tobin, he said: "Unfortunately the sun hasn't shined quite so quite so brightly on my co-workers."
Later in the show Piers said he didn't really need make-up and added: "People think I've had plastic surgery I look so good."
It seems fans agreed, taking to Twitter to compliment the TV host on his appearance.
One wrote: "Piers you look dashing loving the hair you look really well and slimmer x"
However, yesterday viewers were convinced Piers' face had undergone something more drastic.
One wrote: "Piers' new face has had more work done to it."
Another commented: "Be honest Piers, you had some [facelift] work done in LA … or have you joined the #Botox crowd at last?"
Replying to a tweet about the new look ITV studio, a third shared: "Piers' new face has had more work done to it."
On Monday Piers returned to the morning show for the first time in several weeks.
During an interview Judge Rinder told Piers: "It's good to see you looking so well Piers. You look like you've had some species of facial."
Panning to Lorraine Kelly in her studio, she jokingly added: "He's had work done. I'll find out!"
Piers has been on "extended break" which has seen him spend time in Los Angeles with his wife Celia Walden.
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