The fashion pioneer is thought to have killed herself after her body was found at her New York apartment, and her family have since told of her struggle with depression.
And Vorderman, 57, known for hosting the beloved Countdown, said on Twitter today that she too has had struggles with mental health.
She told her followers: "Such sad news.
"I don't know the circumstances for Kate Spade BUT many women in their 50s go through similar feelings… I did.
"It was diagnosed correctly as hormonal imbalance and I was 'cured' with bio identical gels within 48 hours. Never a similar thought since."
Spade, 55, was yesterday discovered in the Park Avenue flat on Manhattan's Upper East Side by her housekeeper with a note left nearby.
The designer launched Kate Spade Handbags in 1993 and developed it into an international brand.
It has more than 300 stores worldwide.
She sold her stake in 2007 to raise her daughter with husband Andy brother of actor David Spade then launched a new brand in 2016 named after Frances, now 13.
Ex-President Bill Clinton's daughter Chelsea led tributes, saying: "My grandmother gave me my first Kate Spade bag when I was in college.
"I still have it. Holding Kate's family, friends and loved ones in my heart."
Her devastated sister Reta Saffo revealed Spade had been suffering with a mental illness for the last three or four years and her suicide "was not unexpected by me".
She said family members had tried to help the mum-of-one get help but she was concerned that seeking treatment might harm the image of the "happy-go-lucky" Kate Spade brand.
A police source told the New York Post: "It was over family problems… in her relationship."
Mr Spade reportedly moved out of the apartment and wanted a divorce, according to TMZ.
However it is believed he was in another room in the flat when their housekeeper discovered her body yesterday morning.
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