The man was found at a block of flats in Woodhouse last night and rushed to hospital.
The teen died in the early hours of this morning and South Yorkshire Police have now launched a murder investigation.
A 17-year-old girl and a 22-year-old man have been arrested in connection with the man's death and both remain in police custody.
A South Yorkshire Police spokesperson said they had been called to the block of flats in Tannery Close just after 11pm last night.
They said: "While formal identification has not yet taken place, his family have been informed and are being supported by specialist officers.
"At this time there are a number of cordons in place in the area, as detectives work to gather evidence and establish the exact circumstances of the incident."
Officers are keen to hear from anyone who saw or heard anything suspicious last night and anyone with information should call 101 quoting incident number 1030 of 22 May 2018.
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