When he announced Inspiration4 in February, Mr. Isaacman said he wanted it to be more than an extraterrestrial jaunt for rich people like him. He reached out to St. Jude Children’s Research Hospital in Memphis, which treats children at no charge and develops cures for childhood cancers as well as other diseases. Mr. Isaacman offered to use the mission as a fund-raising vehicle for St. Jude, setting a $200 million target.

“If you’re going to accomplish all those great things out in space, all that progress, then you have an obligation to do some considerable good here on Earth, like making sure you conquer childhood cancer along the way,” he said.

So far, more than $130 million has been raised including the $100 million that Mr. Isaacman is personally donating to St. Jude.

“We are elated with where we are from a fund-raising perspective,” said Richard C. Shadyac Jr., the president of ALSAC, the fund-raising organization for St. Jude. “I couldn’t be more pleased. We’ll continue to strive for that $200 million goal.”

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