India claims it has spotted a 'double mutant' Covid variant

India claims it has spotted a ‘double mutant’ Covid variant that spreads easier and may escape vaccines… but British scientists say there’s no reason to panic

  • Indian experts spotted variant in samples in the western state of Maharashtra
  • Claim it’s hybrid of two variants that merged together inside an infected person
  • But British scientists say there is no evidence and criticised India’s ‘bold claims’ 

India today claimed it has spotted a ‘double mutant’ Covid variant that may spread easier and make vaccines less potent. 

Government-backed researchers detected the strain in samples taken in the western state of Maharashtra. 

They suggested the variant is a hybrid of two different Covid strains — a rare event which occurs when two viruses merge together inside an infected person. 

Indian health officials said the variant’s mutations suggest a risk of ‘immune escape and increased infectivity’. But they added that the variant had not been detected in high enough numbers to be behind India’s latest wave of infections.

The variant, yet to be named, has two main mutations that concern experts. E484Q and L452R — both found on the spike protein, which the immune system targets to fight off the coronavirus — are thought to play a role in transmissibility and antibody escape.

However, British scientists told MailOnline today there was ‘no evidence’ to suggest the virus is a ‘recombination variant’, when two strains merge.

Dr Simon Clarke, a molecular biologist at Reading University, said it was more likely to be another variant that randomly spawned with those two mutations.

He added: ‘We should not try to make this out to be something it’s not because it is most likely the same thing we’ve seen in other variants, like the one in Brazil and South Africa — which all have multiple mutations on their spike protein. I’ve not yet seen any evidence to suggest it is a recombinant.’ 

Only one hybrid version of coronavirus has been spotted so far. It was found in the US and was a mix between the Kent variant and a strain found in California.

India today claimed it has discovered a double mutant coronavirus variant which has two mutations on its spike protein and may be more infectious and immune resistant  

Three cases of the New York variant have been identified in the UK, which may have been here for at least a month. They carry the E484K mutation, which can make vaccines less effective

Dr Clarke criticised the Indian health ministry for claiming the variant may be more infectious and immune resistant, describing the claim as ‘a bit bold’.

Dr Clarke added: ‘It’s entirely possible that it will turn out this variant does have some immune resistance, but the claim is definitely rather bold.’

For a combined variant of the virus to emerge, one person must be infected with two strains of the coronavirus – likely from two separate sources – at the same time, and then the viruses must bump into each other inside the body. 

Once the viruses are inside the body, the way they spread is by forcing human cells to make more of them. 

The coronavirus is made up of genetic material called RNA and, to reproduce, it must force the body to read this RNA and make exact copies of it.

There are inevitably errors when this happens because it happens so fast and so often and natural processes are imperfect. 

If two viruses are in the same place at once, both being duplicated by the same cells, there is a chance the RNA genes could be mixed up, just as there could be a mix-up if someone dropped two packs of cards at once and picked them all up.

Most places have dominant variants of the virus so someone getting infected with two is unlikely to begin with. 

And, for healthy people, there is likely only a window of around two weeks before the body starts to develop immunity and successfully clear out the first version of the virus. 

This risk window could be cut to days for the majority of people who develop Covid symptoms  – which takes an average of five days – and then stay at home sick.

But huge, poorly controlled outbreaks like the ones in the UK and US over the winter, significantly raise the risk of the combination events simply because the number of infections is higher. 

He explained the E484Q mutation is a less radical change than the E484K found on the Brazilian and South African variants.

For this reason, Dr Clarke suspects E484Q will not have the same effect as E484K, which makes immunity from vaccines and previous infection weaker.

Dr Clarke said: ‘And as for the L452R mutation, we’re still waiting for a proper definition on what it does.’

The new Indian variant was spotted through genomic sequencing, when scientists analyse the genes of individual samples of positive Covid tests.  

The government samples collected from Maharashtra showed ‘an increase in the fraction of samples with the E484Q and L452R mutations’ compared with December last year. 

It’s not clear how many cases of the variant were detected, but the government denied that the rise in case numbers was linked to the strain.

In a statement, it said: ‘Though VOCs [variants of concern] and a new double mutant variant have been found in India, these have not been detected in numbers sufficient to either establish a direct relationship or explain the rapid increase in cases in some states.’

In total, scientists from the Indian SARS-CoV-2 Consortium on Genomics (INSACOG) looked at 10,787 samples from 18 states. 

A total of 736 were positive for the UK variant, 34 for the South African variant and one for the Brazilian P.1 variant. 

Only one hybrid Covid variant has been spotted worldwide so far. It was formed from the Kent Covid variant – known scientifically as B.1.1.7 – and a Californian variant called B.1.429.

Scientists in the US claim they merged in a ‘recombination event’, the New Scientist reported. 

This happens when two different versions of the virus infect the same cell and then swap genes while they are reproducing, giving rise to a new variant.

Researchers have warned in the past that these events are possible but said they are ‘unlikely’ because they require very specific conditions and the coincidence of mostly uncontrollable events. They are more likely to happen during huge outbreaks.

It is believed to have happened in this instance because a number of mutations matching those on the Kent and California variants all appeared in the same place at once. 

There are no details of the patient and it is unclear whether the combination happened in them, or whether they caught the variant from someone else.

While experts have said there is no need to panic about new variants, one admitted recombination was ‘dangerous’ because it could change the virus so suddenly.

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