The Lazio winger, 25, flew into London on Thursday night and will undergo a medical on Friday to become the big-spending Hammers’ sixth and biggest signing of the summer in the next 48 hours.
West Ham have busted the bank by agreeing to pay around £41m for Anderson with a further £6m in add-ons.
It is more than double the previous biggest spend which was £24m on centre-half Issa Diop from French side Toulouse.
Anderson will join fellow new boys Andriy Yarmalenko, Jack Wilshere, Lukas Fabianski and Ryan Fredericks as part of the Hammers’ new stable in a major revamp of the squad following the arrival of Manuel Pellegrini as manager.
The squad is heading home from a training camp in Switzerland today but with some gloomy news as it emerges that injury prone striker Andy Carroll needs ankle surgery and will be out for three months.
The same goes for centre-half Winston Reid who needs an op on his knee and will be sidelined for a similar amount of time.
Pellegrini said: "We are obviously very sad to hear that Andy and Winston have suffered setbacks.
"This is a big blow for them and us, but we hope to see them back in action as soon as possible.
"It does mean that we have lost two senior players in key areas, though, and we’ll continue to work hard with the owners to make further additions to strengthen the playing squad, beyond the five new signings already confirmed."
West Ham are also being linked with a shock move for Lyon centre-back Marcelo as Pellegrini continues on his summer shopping spree.
The Hammers are preparing a £20m offer for the defender.
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