Former England Under-21 keeper Bettinelli, 26, is being drafted in for the games with Spain and Switzerland.
Earlier in the day, Raheem Sterling pulled out of England's squad with a lower back problem.
The 23-year-old would almost certainly have started Saturday's Nations League clash with Spain at Wembley.
And things could get worse for Southgate and Co for their Uefa Nations League openers – with Adam Lallana also an injury worry.
The Liverpool star started the session at St George's Park today – the Three Lions' first since the World Cup – but left the pitch early as a precaution with a groin strain.
THE ENGLAND SQUAD IN FULL
Jack Butland (Stoke), Alex McCarthy (Southampton), Jordan Pickford (Everton), Marcus Bettinelli (Fulham)
Trent Alexander-Arnold (Liverpool), Joe Gomez (Liverpool), Harry Maguire (Leicester), Danny Rose (Tottenham), Luke Shaw (Manchester United), John Stones (Manchester City), James Tarkowski (Burnley), Kieran Trippier (Tottenham), Kyle Walker (Manchester City)
Dele Alli (Tottenham), Fabian Delph (Manchester City), Eric Dier (Tottenham), Jordan Henderson (Liverpool), Adam Lallana (Liverpool), Jesse Lingard (Manchester United), Ruben Loftus-Cheek (Chelsea)
Harry Kane (Tottenham), Marcus Rashford (Manchester United), Danny Welbeck (Arsenal)
But the main news from today is Bettinelli, who only last season was sitting on the bench at then-Championship side Fulham.
The keeper spent much of last term on the sidelines before a late-season surge saw him reclaim the No1 jersey.
Bettinelli worked his way through the Cottagers' youth ranks and has earned one cap at Under-21 level – in 2015.
The Fulham No1 has played two games this season, in the most recent games against Burnley – a 4-2 win – and the 2-2 draw with Brighton.
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